AST 487 - CAS# 630124-46-8 Size:Solid 2 mg Both of these cannot be

Both of these cannot be attributed directly to inhibition of IκB-α kinase but to inhibition of an upstream regulator of IKKα

22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H

PND-1186 treatment caused downregulation of FAK Tyr-397 phosphorylation and cyclin D1 amount (Supplementary Figures S8c and d) and increased the expression of both p21 and cleaved caspase-3 at 48 h (Figure 8b)

4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1

Solubility: DMSO: 100 mg/mL(147

AST 487 - CAS# 630124-46-8 Size:Solid 2 mg Both of these cannot beAST487, also known as NVP AST487, is a RET kinase inhibitor FLT3 inhibitor. The RET kinase has emerged as a promising target for the therapy of medullary thyroid cancers (MTC) and of a subset of papillary thyroid cancers. NVP AST487 has an IC(50) of 0. 88 mumol L on RET kinase, inhibits RET autophosphorylation and activation of downstream effectors, and potently inhibited the growth of human thyroid cancer cell lines with activating mutations of RET